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Chemical services

Design and synthesis of organic compounds via either FTE or Fee for Service

Custom synthesis and rapid scale-up (mg to kg)

Library design and synthesis

Synthetic route scouting

Medicinal chemistry services

CDS provides a wide range of hit-to-lead and lead optimization services as a part of integrated drug discovery services supported by advanced instrumentation and a strong team of scientists.
1 Hit identification and target validation Route scouting and synthesis of focused library of compounds In vitro and In vivo screening of compounds for optimization.
2 Hit to Lead optimization .Hit expansion with support from high-throughput synthesis. .Design of novel analogues with the help of conventional and computational chemistry methods. .Optimization of leads via multi-parameter optimization approach.

An efficient strategy for the discovery of kinase inhibitors by combination of diversity-oriented synthesis and selective screening is developed. Med. Chem. Commun., 2016, 7, 1946. Patent: 201110066820.7

A novel tricyclic thiazepine compound as a tubulin polymerization inhibitor against H460TaxR,IC50 = 350 nM. Cell Death and Disease, 2016, 7, e2143;Patent: WO 2012/163236 A1.

Process research and development services

Synthetic route scouting
Investigate alternative chemistry to achieve
the bet ter synthetic output
Process optimization
optimize the reaction conditions to achieve the
more efficient and practical compound production

Some early projects by CDS scientists

Process optimization

Peptide chemistry services

Contact us

Changchun Discovery Sciences, Ltd.

Address: Shunda Road 789, Changchun, Jilin, P. R. China


TEL:+86-431-85188877

E-mail: sales@jdty.com

Consultation: 13039301730

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